Ensure Consistently Dry Sterile Products with Fast, Non-Destructive Headspace Analysis
Confirm vacuum retention in every lyophilized vial, without opening one
- Detects loss of vacuum non-destructively by measuring the actual increase in headspace pressure caused by a leak
- Deterministic, quantitative pressure measurement, read directly through the container wall
- Suitable for ampoules, vials, and bottles
- Works on both clear, amber, molded and tubing containers
- Delivers results in seconds, supporting full-batch inspection instead of destructive sampling
Replace Karl Fischer with a faster, non-destructive moisture determination
- Measures headspace moisture non-destructively, and within seconds
- Removes the need to sacrifice product for destructive Karl Fischer testing
- Maps moisture across an entire freeze-dried batch in less than a day, to easily reveal wet spots on the lyo shelf
- Supports lyo cycle optimization and freeze dryer qualification with batch-wide, location-specific data
- Applicable to water vapor permeation and moisture-related product degradation studies
Why choose LIGHTHOUSE?
- Rapid, non-destructive and quantitative headspace moisture and pressure measurements from the industry leader in laser-based headspace analysis
- Patented laser absorption technology, originally developed with funding from the FDA
- Custom change parts hold each sample in a consistent position for repeatable measurement across container types and sizes
- Calibrated against NIST-certified moisture and pressure standards for verified accuracy
- Compact benchtop footprint (30.5 x 30.5 x 29.2 cm) fits directly into existing lab or at-line workflows
- Easy-to-use hardware and software require minimal operator training
The FMS-Moisture/Pressure Headspace Analyzer
The FMS-Moisture/Pressure Headspace Analyzer
FMS-Moisture/Pressure
SPECIFICATIONS
Trusted by the pharmaceutical industry
- More than 30 years of experience in laser-based headspace analysis
- Used by all of the top 10 global pharmaceutical companies
- GMP certified services aligned with global regulatory expectations
Our other benchtop instruments
FMS-Carbon Dioxide
The FMS-Carbon Dioxide Headspace Analyzer enables the rapid non-destructive analysis of headspace carbon dioxide in sealed parenteral containers. Applications include container closure integrity testing and automated inspection of media fill containers.
FMS-Oxygen
The FMS-Oxygen Analyzer enables precise, non-invasive oxygen analysis in sealed containers — ideal for pharma QC, process validation, and container closure integrity testing (CCIT).
FMS-Water Activity
Reactive moisture drives degradation, caking, and stability failures in solid dosage and lyophilized product, yet Karl Fischer titration and loss on drying destroy the very samples you need to monitor over time. The FMS-Water Activity Analyzer measures water activity non-destructively, straight through the container.
Learn more about...
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Equipment Lease
Our flexible lease option allows clients to plan for short… — Read more -
A Rapid Non-destructive Approach for Moisture Determination of Lyophilized Product
​​​​​​In this webinar, Dr. Derek Duncan and Dr. Paula Bracco… — Read more -
Water Activity: A Better Approach for Lyo Moisture Determination
— Read more
Get in touch with Jay
Do you have questions about our services or need expert advice for your project? Our dedicated team is here to help. Contact us today to learn how we can support your specific needs.
