Application Note: Stopper “Pop-Up” effects on CCI of Freeze Dried Vials

Container closure integrity plays an important role in maintaining the stability and sterility of lyophilized products. In a freeze drying process, seal integrity must be maintained once the shelves are raised. However, it is possible for stoppers to “pop-up”, allowing gas ingress into the vial headspace, before vials are capped.

Download the Application Note to learn how headspace CCI testing can be used to identify stopper “pop-up” issues for freeze-dried product.