Article: Impact of Water Activity on the Chemical and Physical Stability of Oral Solid Dosage Products

Generally, a variety of specific tests are necessary to evaluate the chemical and physical characteristics of an oral solid dosage formulation throughout the product life cycle. This article describes three case studies in which high moisture caused detrimental effects to the potency and/or dissolution of oral solid dosage products. Direct measurements of the product water activity can be used to characterize these effects.