Maintaining container closure integrity (CCI) is crucial for pharmaceutical product sterility and stability. Traditional CCI tests can be time-consuming, destructive, and lack sensitivity. This study introduces a rapid, non-destructive method using carbon dioxide as a tracer gas and headspace analysis for detection.

The method successfully detected various defect types and sizes in both empty and filled vials, demonstrating its potential as a versatile and efficient alternative for conventional CCI testing. Read on to discover how this approach can enhance your product quality assurance.