Is your cryogenic storage truly secure?
As pharmaceutical products increasingly require ultra-low temperatures between −150°C and −190°C, standard vial systems may no longer guarantee full protection. At these extreme conditions, invisible breaches in container closure integrity (CCI) can occur—jeopardizing product stability, sterility, and ultimately, patient safety.

This article explores a cutting-edge laser-based headspace oxygen analysis method that detects both temporary and permanent CCI failures in cryogenically stored vials. Backed by experimental data across multiple vial types, this technique reveals leaks as small as 5 μm and uncovers vulnerabilities you can’t afford to ignore.

Whether you’re in quality assurance, packaging development, or cryogenic logistics, this is essential reading.