Benchtop Instruments

LIGHTHOUSE introduced the first laser-based FMS-Oxygen Headspace Analyzer into the pharmaceutical industry in 2000 with funding from the Food and Drug Administration.
Three white electronic devices labeled as headspace analyzers for carbon dioxide, moisture and pressure, and oxygen, with assorted small bottles in front of them.

FMS Headspace Analyzers

Frequency Modulation Spectroscopy (FMS) is utilized by LIGHTHOUSE to determine the amount of gases within the headspace of pharmaceutical containers. Using laser absorption, light from a near-infrared laser is tuned to match an internal absorption frequency of various molecules and passed through a glass sample container in the headspace above the product. The amount of laser light absorbed is proportional to the concentration of the specified gas in the headspace.


The rapid and non-destructive nature of the analysis allows for multiple measurements on the same sample over time, which yields more accurate results. Additionally, this prevents waste, which saves costs on both waste disposal items and valuable product.


The benchtop FMS Headspace Analyzers are straightforward to use, meaning operators do not require special expertise to use these robust, portable devices, and accuracy does not depend on operator skills.


FMS Headspace Analyzers

Key features

  • Rapid non-destructive measurement allows for 100% inspection
  • High-sensitivity signal analysis delivers an accurate measurement in seconds
  • Custom change parts provide consistent positioning of sample for optimal measurement across a wide range of container types and sizes
  • Certified Gas Standards, traceable to NIST
Three identical desktop diagnostic machines with screens, including a Carbon Dioxide Analyzer, are lined up in a row on a laboratory benchtop, each accompanied by keyboards and computer mice.


All FMS Headspace Analyzers are provided with a basic software package. For enhanced compliance features and centralized data management, the additional GxP Database Package is available:

  • System audit trail
  • Data is stored in a secure database
  • Results are logged at the time of measurement
  • Electronic signatures for review & approval
  • Password protected software access
  • Access to raw data & searchable for easy retrieval of data or user events
A scientist in a lab coat works with equipment in a laboratory. Foreground shows small clear bottles with blue and red caps. The equipment is labeled

Installation and Support

LIGHTHOUSE Technicians can assist you with the following services:

  • System startup and installation
  • System qualification (IQ/OQ/PQ and Method support)
  • User training
  • Preventative maintenance
  • Troubleshooting

LIGHTHOUSE offers a complete set of validation protocols, as well as on-site qualification services designed to assist customers in their validation efforts of LIGHTHOUSE systems. The validation documentation can be modified to fit a customer’s particular document format standard.