A person wearing a lab coat places a vial into a FMS-Oxygen Headspace Analyzer

Oxygen Monitoring

Maintaining low headspace oxygen levels is essential for the stability and potency of oxygen-sensitive products. LIGHTHOUSE provides non-destructive, laser-based oxygen monitoring solutions suitable for manufacturing, development, and quality control.

LIGHTHOUSE headspace oxygen monitoring enables

  • Rapid and non-destructive oxygen determination
  • 100% inspection of drug products
  • Rapid purge optimization of filling lines
  • Data-driven selection of optimal primary package
  • Stability studies over the product shelf life

Oxygen Monitoring for Sterile Filling Lines

To protect oxygen sensitive drugs, sterile filling lines require consistent low-oxygen headspace.

Fast, robust oxygen monitoring ensures optimal product stability by efficiently characterizing and validating filling lines.

Non-destructive headspace oxygen analysis replaces traditional destructive methods, accelerating data generation and improving process insight.

 

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Headspace Oxygen Determination

Headspace Oxygen Determination

Close up of LIGHTHOUSE 100% headspace inspection machine.

Nitrogen purge characterization, optimization and validation

Reaching low headspace oxygen levels is critical for oxygen-sensitive products.

Non-destructive headspace analysis allows precise performance monitoring of filling lines, ensuring consistent results during filling.

LIGHTHOUSE analyzers enable both at-line and 100% in-line inspections, immediately after sealing.

This approach streamlines nitrogen purge optimization and qualification, supporting in-process control during production.

 

 

 

Optimization and qualification of nitrogen purge in manufacturing
A LIGHTHOUSE scientist preparing samples for a scientific study

Primary Package Selection and Stability Studies

For oxygen-sensitive products, primary package choice is crucial to maintain stability and efficacy over the shelf life.

Exposure to oxygen can reduce potency, change dissolution rates, or even introduce toxicity.

LIGHTHOUSE offers packaging and permeation studies to ensure container closure integrity over shelf life.

Headspace oxygen analysis supports packaging selection and stability assessments, helping determine when antioxidants are depleted, signaling potential oxidation risks.

 

 

LIGHTHOUSE Analytical Services supports you with your packaging decisions and stability studies
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